______ hungry I am, I never seem to be able to finish off this loaf of bread.

A. Whatever          B. Whenever                 C. Wherever                 D. However

______ bright a talker you are, there are time when it’s better to remain silent.

A. Whatever           B. However                     C. Whenever         D. Whoever

In the global economy, a new drug for cancer, _________ it is discovered, will create many economic possibilities around the world. 

A. whatever                B. whoever          C. wherever        D. whichever

_______ difficult and challenging the task may be, we must finish it on time, because there is a possibility _______our work will go down in history.

A. Whatever; that           B. However; as

C. Whatever; which       D. However; that

 In the global economy, a new drug for cancer,           it is discovered, will create many economic possibilities around the world.

A. whatever         B. whoever       C. wherever     D. whichever