--- What’s the    , Lily?
--- Nothing. I just feel a little tired.
A. question         B. matter               C. wrong

What’s ____ with you, Ann?
A. the matter    B. the wrong   C. matter

 ----What’s up ?

----I failed in the examination of Physics.　

A. How are you?               B. What’s matter with you?

C. What are you doing?          D. What’s wrong with you?

What’s the matter with you?

A．the wrong         B．trouble           C．wrong            D．the weather